Buy Atopica For Dogs

Buy Atopica For Dogs === https://ssurll.com/2tlrFA

Atopica for Dogs is used to treat atopic dermatitis (commonly called skin allergies) in dogs. Signs of skin allergies include itching, scratching, licking, gnawing, chewing, skin infections, hair loss, terrible odor, and sleepless nights. Atopica for Dogs requires a prescription from your veterinarian.

Atopica targets the immune cells involved in the allergic reaction. You usually only administer one dose a day to control symptoms, but many dogs can be effectively controlled with every-other-day or twice-weekly dosing.

Not for human use. Keep this and all drugs out of the reach of children. For use in dogs only. Wear gloves during administration. Capsules should not be broken or opened. Wash hands after administration. In case of accidental ingestion, seek medical advice immediately and provide the package insert or the label to the physician. There are many possible drug interactions. Be sure to tell your veterinarian what other medications your pet is currently using. Give Atopica at least one hour before food or 2 hours after food.

Notify your veterinarian immediately if your pet develops fever (over 103°), painful urination, tiredness, sneezing, coughing, or runny nose. These symptoms could be early signs of dangerous side effects. Don't use in dogs with a history of neoplasia, with a hypersensitivity to cyclosporine, or in reproducing dogs. Use with caution in dogs with diabetes mellitus or renal insufficiency, and with drugs that affect the P-450 pathway. Killed vaccines are recommended. Atopica is a systemic immunosuppressant that may increase susceptibility to infection and development of neoplasia. See product label for complete safety information.

Atopica for Dogs (cyclosporine modified) is an immunosuppressant available by prescription. Atopica is FDA approved for use in the treatment of atopic dermatitis in dogs at least 6 months of age weighing at least 4 lbs. Atopica for Dogs is available in 15 capsule blister packs in strengths of 10 mg for dogs 4-9 lbs, 25 mg for dogs 9.1-16 lbs, 50 mg for dogs 16.1-33 lbs and 100 mg for dogs 33.1-64 lbs. For dogs 64.1-79 lbs, give a combination of one 100 mg capsule and one 50 mg capsule as a single dose. For dogs 79.1-121 lbs give, two 100 mg capsules as a single dose. Atopica for Dogs is given once a day to start until satisfactory improvement is seen, usually 4 to 8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days.

Fourteen dogs withdrew from the study due to adverse reactions. Four dogs withdrew from the study after vomiting. One dog each withdrew from the study after diarrhea; vomiting, diarrhea and pruritus; vomiting, depression and lethargy; lethargy, anorexia and hepatitis; gingival hyperplasia, lethargy, polyuria/polydipsia and soft stool; seizure; sebaceous cyst; pruritus; erythema; or otitis externa.

Persistent otitis externa, urinary tract infections, anorexia, gingival hyperplasia, lymphadenopathy and lethargy were the next most frequent adverse events observed. Gingival hyperplasia regressed with dose tapering. Owners of four dogs reported seizures while dogs were receiving Atopica. In one dog, seizures were the result of a brain tumor diagnosed one month into the study. Another dog experienced seizures before and after the study.

Otitis externa, allergic otitis, or pinna erythema, with or without exudates, commonly accompanies atopy. Many dogs entered the study with otitis externa, which did not resolve without otic treatment. New cases of otitis externa, allergic otitis, or pinna erythema developed while dogs were receiving Atopica. However, the incidence rate was lower with Atopica compared to placebo. A change in the dose frequency was not necessary when new cases occurred.

The following clinical signs were reported in less than 2% of dogs treated with Atopica in the field study: constipation, flatulence, Clostridial organisms in the feces, nausea, regurgitation, polyuria/polydipsia, strong urine odor, proteinuria, pruritus, erythema/flushed appearance, pyoderma, sebaceous adenitis, crusty dermatitis, excessive shedding, coarse coat, alopecia, papillomas, histiocytoma, granulomatous mass or lesion, cutaneous cyst, epulis, benign epithelial tumor, multiple hemangioma, raised nodule on pinna, seizure, shaking/trembling, hind limb twitch, panting, depression, irritability, hyperactivity, quieter, increased light sensitivity, reluctance to go outside, weight loss, hepatitis.

The following clinical signs were observed in 1.5-4.5% of dogs while receiving the placebo: vomiting, diarrhea and urinary tract infection. The following clinical signs were observed in less than 1% of dogs receiving the placebo: anorexia, otitis externa, cutaneous cysts, corneal opacity, lymphadenopathy, erythema/flushed appearance.

In addition, the following changes in clinical chemistry parameters were noted in less than 2% of dogs: hypernatremia; hyperkalemia, elevated ALT, elevated ALP, hypercalcemia and hyperchloremia. These clinical pathology changes were generally not associated with clinical signs.

Evaluations for pruritus and for skin lesions to derive a Canine Atopic Dermatitis Extent and Severity Index (CADESI) score occurred at enrollment and at monthly intervals. One hundred ninety-two (192) dogs were included in the statistical analysis of effectiveness.

At the end of the 30 day placebo controlled period, CADESI scores of dogs treated with Atopica capsules improved by 45% from enrollment, while CADESI scores of dogs treated with placebo worsened by 9%. Seventy-four percent (74%) of Atopica treated dogs showed improvement in their pruritus scores over the first 30 day period, while only 24% of the placebo treated dogs showed an improvement. Owner and Veterinary Global Assessment in response to treatment also demonstrated statistically significant (p

Improvements in pruritus accompanied by 50% or 75% improvements in CADESI scores resulted in dose reductions to every other day or twice weekly respectively. Not all dogs were able to decrease to twice weekly dosing. Some animals required upward or downward dosage adjustments during the study. Such adjustments should be expected during therapy of this disease. Dogs unable to decrease from once daily dosing after 60 days were considered dose reduction failures for the purposes of the study.

In a 90-day study with Atopica, dogs were dosed in one of two patterns: either 1, 3, or 5X the maximum recommended target initial daily dose for 90 days, or 1, 3, or 5X the maximum recommended target initial daily dose for 30 days followed by tapering to mimic the recommended clinical dosing pattern. The maximum recommended dose, when administered for 90 days causes callus-like lesions on the footpads, red/swollen pinnae, mild to moderate gingival proliferation, hyperkeratotic areas on the integument, hair loss, salivation, vomiting, and diarrhea/abnormal stools. These clinical signs lessened in severity or resolved as the drug was tapered to a lower dose. Increased erythrocyte sedimentation rate, hyperproteinemia, hyperglobulinemia, hypoalbuminemia, hypocalcemia, hypophosphatemia, and hypomagnesemia were observed at three and five times the maximum recommended dose. These resolved as the dose was tapered.

Gross necropsy revealed epithelial changes consistent with those seen on physical examination. Proliferation of gingiva and toe pad epithelium was seen in all Atopica dosed groups, and was seen in a dose dependent fashion. The degree of the proliferation was greater in dogs in the non-tapered groups as compared to the tapered groups. Similar changes were noted on histopathologic examination of the cutaneous changes seen on physical examination. These lesions were characterized by epidermal hyperplasia, chronic dermatitis and hyperkeratosis. 59ce067264

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